How it works
DENARASE^® High Salt is an engineered version of the wild-type Serratia marcescens endonuclease, which is commonly used for DNA removal applications in bioprocessing. Compared to the wild-type DENARASE^® a few amino acids were substituted to provide the enzyme with an improved salt tolerance without losing its specificity for nucleic acids. DENARASE^® High Salt shows higher activity over a wider range of salt concentrations and pH levels and so offers greater flexibility in bioprocessing.
Because of the great similarities to the wild-type enzyme, DENARASE^® High Salt can be detected using the same Serratia marcescens endonuclease ELISA Kits, such as DENARASE^® ELISA Kit.

Production of DENARASE^® High Salt
DENARASE^® High Salt is produced using our established, proprietary DENARASE^® manufacturing process which is based on the expression in a gram-positive Bacillus sp. strain. The enzyme is produced under ISO 9001 standard, without the use of antibiotics and raw materials of animal origin or TSE/BSE risk.