[No.NP892-041] iMatrix 411 (350 ug: 175 ug × 2 tube/box)
Recombinant Laminin-411 E8-Fragments
iMatrix-411 features make it an ideal matrix for some cell culture applications:
- Xeno-free formulation / CHO-S cell bioproduction
- Easy to use (liquid format)
- E8-fragments retain integrin binding specificity and capacity, and display higher potency than natural Laminin-411
- Cultivation of iPSC on iMatrix-411 induces a cell fate transition to endothelial progenitor cells
iMatrix-411 is a highly purified and refined product of human recombinant laminin-411 (E8 fragment) expressed by CHO-S cells. Laminin-411 is found predominantly expressed in the vascular endothelial basement membrane1 and in Langerhans islet capillary endothelial cells of the pancreas.2
As a cell culture ECM-substrate iMatrix-411 can assist in establishing human endothelial cell primary cultures from fresh human bio-specimens.
Human iPS cells, when cultured on iMatrix-411, are robustly induced (>95%) to differentiate into endothelial progenitor cells with angiogenesis capacity.1 Other published reports have used iMatrix-411 and iMatrix-511 in a step-wise protocol to generate cholangiocytes capable of forming 3D cyst-structures from iPSC-derived hepatoblastic cells.3
SPECIFICATION
Product Name
iMatrix-411 Endothelial Cell Substrate
Catalog Number
NP892-041
NP892-042
Size
- NP892-041: 2 × 175 µg
- NP892-042: 6 × 175 µg
Molecular Weight
150 kDa
Purity
>95% pure
Formulation
Purified Laminin-411 E8 proteolytic fragment
Storage and Stability
Store at 4 °C and protect from light exposure. Stable for 2 years from manufacturing date.
Quality Control
Activity: Kd for integrin binding
Sterility
Sterile
Notice To Purchaser
REPROCELL is a licensed distributor of Matrixome cell culture substrates to the global market
Recommended Usage
iMatrix-411 is suitable for use as a substrate for culture of various cell types, but most notably for vascular endothelial cells.
Concentration
500 µg/mL
Source
CHO-S cell expression
Manufacturer
Matrixome Corporation (Japan)
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