[No.NP892-012] iMatrix 511 (1,050 ug: 175 ug × 6 tube/box)
Recombinant Laminin-511 E8-Fragments
iMatrix-511 is a highly purified and refined laminin-511 E8 fragments, produced in CHO cells.
iMatrix-511 features make it an ideal matrix for pluripotent stem cell culture:
- Promotes greater stem cell adhesion than all other matrix proteins that have been tested
- Easy to use (liquid format)
- E8 fragments retain integrin binding specificity and capacity, and display higher potency than natural Laminin-511
- Equivalent performance, but lower cost than the legacy iMatrix-511 product
Laminin is localized to the basement membrane, and plays a key role in cell adhesion and proliferation. Laminin-511 (α5, β1 laminin) binds to integrin α6β1 to promote cell signaling. Laminin-511 provides an ideal matrix for the proliferation of a wide variety of cell types including stem and iPS cells.
iMatrix-511 is functionally equivalent to iMatrix-511 SILK (Cat. No. NP892-021). The only difference is the expression system used for bioproduction. The iMatrix-511 SILK product is produced in recombinant silkworm cocoon, while iMatrix-511 is produced in CHO-S cells. Both are E8 fragments that have been purified using the same processes.
SPECIFICATION
Product Name
iMatrix-511 Stem Cell Culture Substrate
Catalog Number
NP892-011
NP892-012
Size
- NP891-011: 2 × 175 µg
- NP891-012: 6 × 175 µg
Molecular Weight
150 kDa
Purity
>95% pure
Formulation
Purified Laminin-511 E8 proteolytic fragment
Storage and Stability
Store at 4 °C and protect from light exposure. Stable for 2 years from manufacturing date.
Concentration
500 µg/mL
Source
CHO cells
Quality Control
Integrin binding Kd < 10 nM
Sterility
Sterile
Notice To Purchaser
REPROCELL is a licensed distributor of Matrixome cell culture substrates to the global market.
Recommended Usage
iMatrix-511 is suitable for use as a substrate for culture of various cell types, including ES/iPS cells.
Manufacturer
Matrixome Corporation (Japan)
RESOURCE
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