[No.04-0004-02] CHIR99021 (2 mg in solution (10mM))
The aminopyrimidine CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3 β (GSK-3β) reported to date1,2. Unlike other potent inhibitors of GSK-3, CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs3. Along with the elimination of differentiation-inducing signaling from mitogen-activated protein kinases, using CHIR99021 to block the activity of GSK-3β enables the self-renewal of embryonic stem cells4.
More information: reprocell.com
SPECIFICATION
Product Name: Stemolecule CHIR99021
Catalog Number: 04-0004
Size
- 2 mg (Cat. No. 04-0004)
- 10 mg (Cat. No. 04-0004-10)
- 2 mg in 10 mM DMSO solution (Cat. No. 04-0004-02)
Alternate Name(s): 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Chemical Formula: C22H18Cl2N8
Molecular Weight: 465.34
CAS Number: 252917-06-9
Purity: Greater than 95 % by HPLC analysis
Formulation: Off-white solid
Solubility: Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.
Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C. The effect of storage of stock solutions should be verified for each application.
Quality Control: The purity of CHIR99021 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of CHIR99021 was tested on mouse embryonic stem cells.
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